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Abstract #3947

Resting state cerebral networks in mouse lemur primates: comparison with humans

Clément M. Garin1, Nachiket N. Nadkarni2, Brigitte Landeau3,4, Jean-Luc Picq2,5, Gaël Chételat3,4, Salma Bougacha3,4, and Dhenain Marc2,6
1Wake Forest University, Winston Salem, NC, United States, 2Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Fontenay aux Roses, France, 3INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine, Normandie University, UNICAEN, EPHE, Caen, France, 4Normandie Univ, UNICAEN, GIP Cyceron, Inserm, Inserm UMR-S U1237, Caen, France, 5EA 2027, Université Paris 8, 5 Laboratoire de Psychopathologie et de Neuropsychologie, Saint Denis, France, 6UMR 9199, Neurodegenerative Diseases Laboratory, 1 Centre National de la Recherche Scientifique (CNRS), Fontenay-aux-Roses, France, France

Characterizing neuronal networks in animals is critical to further address their evolutions. Here we compared brain networks in humans and in mouse lemurs (Microcebus murinus), one of the more phylogenetically distant primates as compared to humans. Network hubs were split into parietal and frontal clusters in humans, while they were grouped in lemurs. Human’s default mode network (DMN) embedded more hubs than lemur's DMN. Mouse lemur's motor network embedded more hubs than human motor networks. Hubness properties could constitute a lever of evolution to adapt information flux to brain size and/or cerebral function.

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