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Abstract #3948

Shaping the BOLD signal through Excitatory and Inhibitory Interaction.

Rik Lodevicus Elizabeth Maria Ubaghs1, Harald Dermutz1, Roman Böhringer1, Markus Marks1, Mehmet Fatih Yanik1, and Benjamin Friedrich Grewe1
1Institute of Neuroinformatics University and ETH Zurich, ETH Zurich, Zurich, Switzerland

Characteristics of neural processing such as recurrent signalling, make the definition of functional neural involvement notoriously difficult. This has implications for fMRI interpretation, and especially the relationship between excitatory/inhibitory networks and the BOLD response has not been well studied. Here we provide evidence that there are stimulus-dependent effects on neural processing in the VISp that could explain previously observed differentiation in BOLD polarity. We hypothesize that this is due to local excitatory/inhibitory interactions, and present a novel fiber-photometry setup that allows us to investigate the neural underpinnings of this effect by measuring excitatory and inhibitory activity during fMRI.

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