Optogenetic fMRI is an attractive tool for studying neuronal manipulation dynamics at multiple scales, but currently lacks techniques for network (i.e. mesoscale) level investigations due to the small illumination volume of traditional flat-faced optical fibers. Here we show that a recently developed tapered fiber design allowed simultaneous, artefact-free illumination of large cortico-hippocampal areas. We also demonstrated that low-frequency cortico-hippocampal entrainment resulted in a prominent functional desynchronization of the mouse default mode network. These results support the use of this technique for deconstructing network-scale substrates and probing brain-wide functional network dynamics.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords