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Abstract #3951

Role of the combination of T2 values and edema volume as a biomarker in evaluating the neuroprotective effect of LITUS to moderate TBI with rat model  

Du Juan1, Zheng Tao1, Yuan Yi2, Wang Zhanqiu1, Liu Defeng1, Shi Qinglei3, Wu Shuo1, Wang Xiaohan1, and Liu Lanxiang1
1MRI, Qinhuangdao Municipal No. 1 Hospital, Qinhuangdao, China, 2Institute of Electrical Engineering, Yanshan University, Qinhuangdao, China, 3Siemens Healthcare, MR Scientific Marketing, Beijing, China

In this study, we verified the feasibility of T2 values combined with edema volume changes in evaluating the neuro therapeutic effect of low-intensity transcranial ultrasound stimulation (LITUS) on post-traumatic brain edema with rat model. The neuro therapeutic effect of LITUS was attributed to inhibiting the expression of AQP4 and promoting the removal of β-APP.

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