Abstract #3950

fMRI investigation of brain plasticity after unilateral cervical spinal cord injury

Basavaraju G Sanganahalli¹, Jyothsna Chitturi², Stella Elkabes³, Peter Herman¹, Fahmeed Hyder¹, and Sridhar S kannurpatti²

¹Radiology and Biomedical Imaging, Yale University School of Medicine, New haven, CT, United States, ²Radiology, RUTGERS-New Jersey Medical School, Newark, NJ, United States, ³Department of Neurological Surgery, RUTGERS-New Jersey Medical School, Newark, NJ, United States

To assess brain plasticity after a unilateral incomplete cervical spinal cord injury (SCI), a complete neural axis assessment was performed using the adult rat model of cervical SCI at the C2/C3 level. Structural T1 and T2-spinal cord anatomical imaging and resting state BOLD-fMRI (9.4T) of the brain was performed 1 month after SCI in sham and SCI animals. The unilateral SCI induced lesion was discernable from anatomical images. Intrinsic brain activity assessed using functional connectivity density (FCD) mapping of global, short-range and long-range connectivity revealed a significant increase in FCD across SCI animals compared to sham.

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