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Abstract #3957

Sensory-evoked fMRI of transgenic mouse is enhanced by deafness

Hyun-Ji Shim1,2, Yoonsun Yang1, Gunsoo Kim1, and Seong-Gi Kim1,2,3
1Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon-si, Korea, Republic of, 2Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University (SKKU), Seoul, Korea, Republic of, 3Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon-si, Korea, Republic of

BOLD fMRI is ideal for investigating neural plasticity of transgenic mouse lines. Visual and somatosensory functions can be reorganized following deafness in the early stage and adult in humans and animals. However, the extent of the neural plasticity remains unclear. To determine how deafness affects other sensory areas, 9.4T BOLD fMRI of sensory stimulation was measured before and after deafening in transgenic adult mice. The impact of scanner noise to evoked responses was also investigated in wild-type mice. Our results suggest that the sensory loss in one modality affects other sensory activities.

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