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Abstract #3958

Brain mechanism of anesthesia and sedation: fMRI functional connectivity study with minimized impact of physiological background noise in rats

Wen-Ju Pan1, Vahid Khalilzad Sharghi1, Xiaodi Zhang1, and Shella Keilholz1
1Emory University/Georgia Institute of Technology, Atlanta, GA, United States

Different anesthetic states and sedation may have varying contributions to BOLD from physiological background noise that may challenge a comparison across brain states. Little is known on brain functional organization between anesthesia and sedation. We used a scan strategy optimized to minimize impact from physiological background noise to examine the effects of different anesthetics on functional connectivity (FC). Our results demonstrate distinct FC patterns across anesthesia depth transition and sedation, providing insight into potential brain mechanisms of unconsciousness that include global modulation of functional connectivity by isoflurane, and distant functional connectivity impairment in dexmedetomidine.

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