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Abstract #3976

Increased Striatal Functional Connectivity is Associated with Improved Smoking Cessation Outcomes

Chao Wang1, Peiyu Huang1, Zhujing Shen1, and Minming Zhang1
1Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Most smoking cessation attempts result in failure. The striatum is critical area of reward processing, and have been repeatedly linked to nicotine addiction. Neuroimaging studies have shown that chronic smokers had altered resting-state functional connectivity (rsFC) of striatum. Here, we further investigated the different rsFC changes of striatum subsets between smokers who relapsed and those who not relapsed after smoking cessation treatment. We found that smokers who relapsed had decreased rsFC of striatum subsets, while those who not relapse had increased rsFC of striatum subsets. These novel findings suggest that increased connectivity of striatum subsets could imporve likelihood of cessation.

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