Abstract #3975

Studying the impact of impaired perfusion and oxygen metabolism on resting-state fMRI-based functional connectivity by simulating blood oxygenation fluctuations

Christine Preibisch^1,2,3, Mario E. Archila-Melendez^1,3, Stephan Kaczmarz^1,3, and Christian Sorg^1,3

¹Department of Neuroradiology, Technische Universität München, School of Medicine, Munich, Germany, ²Clinic of Neurology, Technische Universität München, School of Medicine, Munich, Germany, ³TUM NIC, Technische Universität München, School of Medicine, Munich, Germany

Functional magnetic resonance imaging (fMRI) of blood oxygenation level dependent (BOLD) signals in the resting state is widely used to study functional connectivity of slowly fluctuating ongoing brain activity (BOLD-FC) in humans, particularly also in patients. While physiological impairments, e.g. aberrant perfusion, are common in neurological and psychiatric disorders, their impact on measured BOLD-FC is widely unknown and ignored. The aim of our simulation study, therefore, was to investigate how alterations in neurovascular coupling influence resting-state BOLD-FC measures. Our results demonstrate crucial impact of neurovascular coupling on BOLD-FC due to changes in CMRO2, CBF, CBV, in both amplitudes and delays.

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