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Abstract #3979

Changes of functional brain topology in cognitively impaired professional fighters

Xiaowei Zhuang1, Zhengshi Yang1, Virendra Mishra1, Karthik Sreenivasan1, Sarah J Banks2, Bernick Charles1, and Dietmar Cordes1,3
1Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, 2Department of Neuroscience, University of California, San Diego, La Jolla, CA, United States, 3University of Colorado, Boulder, Boulder, CO, United States

In this study, we utilized graph-theory to investigate functional brain topological alternations in cognitively impaired active professional fighters, as compared to cognitive non-impaired fighters. We observed reduced global and local efficiency across multiple sparsity levels, suggesting that both functional integration and segregation were affected in cognitively impaired fighters. A different functional topological organization was further observed in impaired fighters, shown by increased number of rich clubs and reduced rich-club edge strength and density. Rich club edge strength and density were further significantly correlated with fighters’ psychomotor speed.

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