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Abstract #3980

The mechanisms of cognitive impairment in patients with pontine infarction:a resting-state fMRI study.

Yingying Wang1, Caihong Wang1, Peifang Miao1, Ying Wei1, Luobing Wu1, Kaiyu Wang2, and Jingliang Cheng1
1Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2GE Healthcare MR Research, Beijing, China, Beijing, China

In order to explore the mechanisms of cognitive impairment in patients with pontine infarction, we recruited 45 patients with chronic pontine stroke and 48 normal controls. The independent component analysis (ICA) and seed-based analysis were combined to explore altered patterns of functional connections in patients based on resting-state fMRI. The different FCs in the stroke patients and the healthy controls, as well as the positive correlation between the FC within the cerebellar network and cognitive function scores, indicate that the disconnection of the cerebellar network may be related to the cognitive impairment in patients with pons stroke.

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