Abstract #3982

Dynamic Changes of the Functional Connectivity in the Default Mode Network across the Spectrum of Alzheimer’s Disease

Hyae Won K Redden¹, Daniel Zhu², Thomas J Grabowski³, and Hesamoddin Jahanian³

¹Bioengineering, University of Washington, Seattle, WA, United States, ²Computer Science, University of Washington, Seattle, WA, United States, ³Radiology, University of Washington, Seattle, WA, United States

Default Mode Network functional connectivity (DMN FC) has been proposed as a non-invasive biomarker for Alzheimer’s Disease (AD). However, the dynamic relationships within the DMN over the course of the disease have not been established. We explored the dynamic FC between the DMN nodes in healthy control, mild cognitive impairment (MCI), and AD subjects using a sliding window analysis of ultrafast resting state fMRI (rs-fMRI) data. Group comparisons revealed significant trends in the dynamic measures of functional connectivity within the DMN across the spectrum of AD, suggesting compensatory systems at work within the DMN as AD progresses.

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