The global incidence of depression is gradually increasing nowadays. However, the exact pathogenesis mechanism is not very clear. Traditional diagnosis approaches to depression usually rely on clinical scales, which is sometimes even subjective. It is essential to make up objective and repetitive methods to diagnose the depression. Resting-state functional magnetic resonance imaging (rs-fMRI) offers a noninvasive technique for detecting and measuring subtle functional brain activities of specific regions. This study aims to explore the change of brain function area in patients with depression and assess the role of these altered brain regions in the pathogenesis.