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Abstract #4002

The Neural Basis for Olfactory Deficits in Alzheimer’s Disease

Peter James Castagna1, Rommy Elyan2, Paul Eslinger3, Qing Yang2, and Prasanna Karunanayaka2
1Psychiatry, Penn State University, Hershey, PA, United States, 2Radiology, Penn State University, Hershey, PA, United States, 3Neurology, Penn State University, Hershey, PA, United States

Deficits in odor-memory and odor-identification are among the first clinical symptoms of Alzheimer’s Disease (AD) and mild cognitive impairment (MCI); however, the neural basis of this observation remains unclear. In this study, we combined independent Component Analysis and olfactory functional magnetic resonance imaging to investigate the relationships between the olfactory network (ON) and the medial temporal lobe (MTL). Our study's results suggest that the functional connectivity between the MTL and ON may be aberrant in MCI and AD patients.

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