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Abstract #4001

Altered brain language network in idiopathic peripheral facial paralysis patients with dysarthria

Wenwen Gao1, Xiaowei Han1, Haimei Li2, Yijiang Zhu3, Lei Du1, Li zhi Xie4, and Guolin Ma1
1China-Japan Friendship Hospital, Beijing, China, 2Fu Xing Hospital, Capital Medical University, Beijing, China, 3Anhui Provincial Hospital, Hefei, China, 4GE healthcare, China, Beijing, China

Dysarthria is a common symptom of facial paralysis (FP). The aim of this study was to investigate the functional alterations of the brain language network in FP patients with dysarthria using resting-state fMRI. We found that the functional connectivity between bilateral language regions was significantly decreased in these patients compared with healthy controls. The decrease of functional connectivity in the language network was positively correlated with the severity of oral paralysis in patients. To sum up, these data suggest that dysarthria caused by facial nerve paralysis may lead to a decrease of neural activity in the brain language network.

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