Abstract #4001

Altered brain language network in idiopathic peripheral facial paralysis patients with dysarthria

Wenwen Gao¹, Xiaowei Han¹, Haimei Li², Yijiang Zhu³, Lei Du¹, Li zhi Xie⁴, and Guolin Ma¹

¹China-Japan Friendship Hospital, Beijing, China, ²Fu Xing Hospital, Capital Medical University, Beijing, China, ³Anhui Provincial Hospital, Hefei, China, ⁴GE healthcare, China, Beijing, China

Dysarthria is a common symptom of facial paralysis (FP). The aim of this study was to investigate the functional alterations of the brain language network in FP patients with dysarthria using resting-state fMRI. We found that the functional connectivity between bilateral language regions was significantly decreased in these patients compared with healthy controls. The decrease of functional connectivity in the language network was positively correlated with the severity of oral paralysis in patients. To sum up, these data suggest that dysarthria caused by facial nerve paralysis may lead to a decrease of neural activity in the brain language network.

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