Abstract #4000

Mapping chemotherapy-induced brain functional network abnormality in breast cancer survivors

Kai-Yi Lin¹, Vincent Chin-Hung Chen ^2,3, Yuan-Hsiung Tsai ⁴, and Jun-Cheng Weng^1,2,5

¹Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, ²Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ³School of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Chemo-brain is common among breast cancer survivors. However, some studies suggested cognitive function deficits may exist before chemotherapy initiation. Our study discovered the functional network alterations in women pre- (C-) and post-chemotherapy (C+) compared with health controls using resting-state functional MRI. The mfALFF showed changes in the prefrontal cortex, bilateral middle, right inferior temporal gyrus, right angular gyrus, left insula, and left caudate among three groups. Graph theoretical analysis demonstrated that the C+ group became inclined toward regular networks and the C- group became inclined toward random networks.

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