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Abstract #4097

Evaluation of a Four-Ring Birdcage Head Coil for 1H Imaging and 13C Spectroscopy at 3 Tesla

Joseph Murphy-Boesch1, Kazu Yamamoto2, Ananda Kumar3, Peter L. Choyke4, and Murali Krishna Cherukuri2
1NINDS, National Institutes of Health, Bethesda, MD, United States, 2NCI, National Institutes of Health, Bethesda, MD, United States, 3Lambda-Z Technologies, Baltimore, MD, United States, 4NCI, NIH, Bethesda, MD, United States

Dissolution DNP with Hyperpolarized 13C requires receive coils optimized for sensitivity and a transmit coil capable of delivering strong B1 fields for the carbon frequency. Here, a dual-tuned, four-ring birdcage head coil is described that can produce a transmit field of >90 microTesla and serve as a receive coil for an MRI system with few receivers. Hyperpolarized 13C spectra localized using 2D-CSI were obtained in 6 seconds from a human pancreatic tumor xenograph grown in the flank of a nude mouse. SNR of 13C spectra obtained from a tumor volume of <1 ml was suitable to measure the lactate/pyruvate ratio.

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