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Abstract #4110

A 13C/31P surface coil to visualize metabolism and energetics in the brain

Manushka V. Vaidya1, Georgios Batsios1, Bei Zhang2, Ryan Brown2, Pavithra Viswanath1, Jan Paska2, Gerburg Wulf3, Aaron K. Grant4, Sabrina Ronen1, and Peder E.Z. Larson1
1Department of Radiology, University of California San Francisco, San Francisco, CA, United States, 2Center for Advanced Imaging Innovation and Research, and Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 3Department of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 4Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States

In this work, we constructed a 13C/31P surface coil for studying cancer metabolism and bioenergetics in the brain. In a single scan session, hyperpolarized 13C-pyruvate MRS and 31P MRS were carried out for a healthy rat brain. A commercial volume proton coil was used for anatomical localization and B0 shimming. Results show good detection of 13C labeled lactate, alanine, and bicarbonate in addition to ATP, phosphocreatine, inorganic phosphate, phosphodiesters and phosphomonoesters from 31P MRS. The coil enables obtaining complementary information within a scan session, thus reducing the number of trials and minimizing biological variability for studies of metabolism and bioenergetics.

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