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Abstract #4111

A method for post-surgical evaluation of targeting accuracy in transcranial focused ultrasound thalamic ablation

Benjamin T Newman1,2, Ana Untaroiu1, and T. Jason Druzgal1,2
1Department of Radiology & Medical Imaging, Division of Neuroradiology, University of Virginia Health System, University of Virginia, Charlottesville, VA, United States, 2Brain Institute, University of Virginia, Charlottesville, VA, United States

MR-guided focused ultrasound ablation targets small thalamic nuclei that are frequently difficult to distinguish from surrounding tissue. The ability to accurately evaluate the success in ablating the target nuclei is essential for predicting treatment outcome and evaluating surgical performance. We show microstructural changes in the thalamus that may prevent accurate post-surgical tractography. We propose a straightforward technique that reconstructs neuronal connections in the pre-surgical brain using the post-operative lesioned area as a seed-region for constrained spherical deconvolution based tractography. The proportion of tracts leading to regions known to be connected to the target nuclei is then evaluated.

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