Abstract #4113

Intraoperative Diffusion Weighted MR Image Contrast during Focused Ultrasound Ablation in a Preclinical Swine Model

Steven P Allen¹, Francesco Prada², Jeremy Gatesman³, Xue Feng¹, Helen Sporkin¹, Yekaterina Gilbo¹, Kim Butts Pauly⁴, and Craig H Meyer^1,5

¹Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ²Neurosurgery, University of Virginia, Charlottesville, VA, United States, ³Center for Comparative Medicine, University of Virginia, Charlottesville, VA, United States, ⁴Radiology, Stanford University, Stanford, CA, United States, ⁵Radiology, University of Virginia, Charlottesville, VA, United States

This abstract presents a preclinical study of intraoperative diffusion weighted imaging (DWI) of focused ultrasound thermal lesions in the thalamus using a novel acquisition sequence. We found that DW imaging can visualize thermal lesions within 10 minutes of ablation. Our study indicates that MR-guided focused ultrasound lesions present a rapid and persistent decrease in apparent diffusion coefficient within minutes after ablation and that diffusion-based lesion classification methods can outperform T2-w based methods.

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