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Abstract #4113

Intraoperative Diffusion Weighted MR Image Contrast during Focused Ultrasound Ablation in a Preclinical Swine Model

Steven P Allen1, Francesco Prada2, Jeremy Gatesman3, Xue Feng1, Helen Sporkin1, Yekaterina Gilbo1, Kim Butts Pauly4, and Craig H Meyer1,5
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Neurosurgery, University of Virginia, Charlottesville, VA, United States, 3Center for Comparative Medicine, University of Virginia, Charlottesville, VA, United States, 4Radiology, Stanford University, Stanford, CA, United States, 5Radiology, University of Virginia, Charlottesville, VA, United States

This abstract presents a preclinical study of intraoperative diffusion weighted imaging (DWI) of focused ultrasound thermal lesions in the thalamus using a novel acquisition sequence. We found that DW imaging can visualize thermal lesions within 10 minutes of ablation. Our study indicates that MR-guided focused ultrasound lesions present a rapid and persistent decrease in apparent diffusion coefficient within minutes after ablation and that diffusion-based lesion classification methods can outperform T2-w based methods.

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