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Abstract #4115

Enhancement of the MRgHIFU therapy using endovascular sono-sensitizers demonstrated in an experimental model of perfused tissue

Orane Lorton1, Ryan Holman1, Pauline Guillemin1, Stéphane Desgranges2, Laura Gui1, Lindsey A. Crowe3, François Lazeyras3, Antonio Nastasi4, Christiane Contino-Pépin2, and Rares Salomir1,3
1Image Guided Interventions Laboratory,University of Geneva, Faculty of Medicine, Geneva, Switzerland, 2University of Avignon, CBSA-IBMM (UMR5247), Avignon, France, 3Radiology Department, University Hospitals of Geneva,, Geneva, Switzerland, 4Research and Development Laboratory, Visceral and Transplantation Service, University Hospital Geneva, Geneva, Switzerland

Magnetic Resonance guided High Intensity Focused Ultrasound (MRgHIFU) is accepted for the non-invasive ablation of localized tumors. Thermal contrast between the target tissue and pre/post focal tissues can be improved for highly perfused tumors by injection of liquid core micro-droplets, used as endovascular sono-sensitizers. We are aiming to provide a substitution model for living organs or perfused ex vivo organs to facilitate the investigation of new sono-sensitizers and sonication paradigms. We are reporting an experimental model that is suitable for MR-guided HIFU studies, offering in situ tunable perfusion rate, multi-compartment structure, and tunable concentration of sono-sensitizers and dissolved gases.

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