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Abstract #4116

Feasibility of rapid diffusion-weighted imaging for monitoring of MR-guided prostate high intensity focused ultrasound ablation

Elena Kaye1 and Oguz Akin2
1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

MR-guided high-intensity focused ultrasound (HIFU) treatment of prostate cancer is a promising non-invasive approach. The outcomes of these treatments can be improved with more accurate visualization of ablative necrosis surrounding a tumor. Diffusion-weighted imaging (DWI) could provide valuable information about tissue viability without injection of contrast. However, currently DWI requires high number of excitations (NEX), averages, takes several minutes and is not practical for intraprocedural monitoring. To make DWI a practical tool for monitoring of prostate HIFU, we propose to replace high NEX DWI acquisitions, with NEX=2 acquisitions and subsequent deep-learning denoising of these image.

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