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Abstract #4119

Selective fast focal switching of high-contrast-ratio magnetocaloric MRI labels with focused ultrasound

G. Wilson Miller1,2, Yekaterina Gilbo2, Stephen Dodd3, Alan P Koretsky3, Hatem ElBidweihy4, and Mladen Barbic5
1Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 3National Institutes of Health, Bethesda, MD, United States, 4United States Naval Academy, Annapolis, MD, United States, 5HHMI - Janelia Research Campus, Ashburn, VA, United States

We describe the use of MRI-compatible focused ultrasound (FUS) for selective fast focal switching of high-contrast-ratio magnetocaloric MRI particle labels. Lanthanum-Iron-Silicon (La-Fe-Si) particles that have sharp first-order magnetic phase transitions at physiological temperatures and MRI field strengths were used as MRI labels. Non-invasive rapid thermal switching of these magnetocaloric MRI particle labels with focused ultrasound was clearly demonstrated at physiological temperatures within a clinical 1.5T MR scanner. We have thereby shown that high differential contrast ratio magnetocaloric MRI labels can be switched non-invasively, rapidly, and selectively under conditions relevant to clinical MRI.

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