Abstract #4118

Evaluate thrombolysis effect of focused ultrasound in different thrombus ages by MRI

Yu-Ting Jiang¹, Po-Hung Hsu², Hao-Li Liu³, Chih-Kuang Yeh¹, and Hsu-Hsia Peng¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ³Department of Electrical Engineering, Chang-gung University, Taoyuan, Taiwan

We aimed to evaluate the thrombolysis effect with variant focused ultrasound (FUS) and microbubbles (MB) conditions in different thrombus ages by MRI. Compared to one-week thrombi, 2-days thrombi presented longer T1 and similar T2, while the total iron content increased with thrombus ages. However, with identical thrombolysis conditions, there is no significant difference of weight loss between two different thrombi ages groups. In conclusion, to characterize the T1 and T2 relaxation times of thrombi with different ages can be helpful for evaluation of the thrombolysis effect with variant UK and FUS conditions in different thrombi ages.

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