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Abstract #4131

Reference-free PRFS thermometry using 3D spherical harmonic functions

Laura Gui1, Orane Lorton1, Max Scheffler2, and Rares Salomir1,2
1Image Guided Interventions Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 2Department of Radiology, University Hospitals of Geneva, Geneva, Switzerland

Magnetic resonance thermometry via the classic time-referenced PRFS method is perturbed by tissue motion and external magnetic field perturbations. We extend an existing 2-D reference-free PRFS thermometry method to 3-D data, by performing near-harmonic reconstruction of the background phase inside a sphere. Ex-vivo HIFU sonication experiments and in-vivo “zero-measurement” of a human brain showed good method accuracy and precision, fast computation times and similar results with the time-referenced PRFS method for motion-free scenarios. This study demonstrates the method’s feasibility for real time thermometry of moving tissues.

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