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Abstract #4133

Real-Time Temperature Monitoring during MR Imaging Guided Photothermal Therapy

Boyu Zhang1, Xianfu Meng2, Yuwen Zhang1, Wenbo Bu2, and He Wang1,3
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China, 3Human Phenome Institute, Fudan University, Shanghai, China

It is a challenge that accurate monitoring the spatial distribution of photothermal transducing agents (PTAs), meanwhile, real-time mapping temperature in photothermal therapy. Here, we propose an effective strategy that integrates T1 and MR temperature imaging for tracking nanoPTAs and real-time temperature monitoring in vivo. The synthesized nanoPTAs equip with favorable T1 performance and marginal susceptibility guaranteeing the accuracy of temperature mapping. The time resolution is 20 seconds, and the detection accuracy of temperature change is as low as 0.1K, which contributes to promoting the clinical application of photothermal therapy.

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