Ultrahigh field (UHF) MR employs higher radio frequencies (RF) than conventional MR and has unique potential to provide focal temperature manipulation and high resolution imaging (ThermalMR), as our simulations and experimental work demonstrated for f=300MHz. Here we use EMF simulations to demonstrate the added value for multi-frequency thermal intervention (f=300MHz-500MHz) to boost the efficacy of the heating paradigm for clinical target volumes (TVs) of two brain tumor patients. An optimization algorithm was developed to study RF power deposition in the TV for a single, double or triple frequency set permitting highest RF power deposition in the TV.
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