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Abstract #4139

MRI-Guided Cryoablation and Image-Guided Immunotherapy in Naturally Occurring Canine Osteosarcoma

Dara Kraitchman1, Cory Brayton1, Rebecca Krimins1, Byung-Hak Kang1, Zachary Millman1, Edward McCarthy1, and Brian Ladle1
1Johns Hopkins University School of Medicine, Baltimore, MD, United States

Improvements in outcomes with current chemotherapy and surgery treatment approaches for patients with osteosarcoma have plateaued over the past three decades necessitating new treatment paradigms. A novel therapy for osteosarcoma of MR-guided cryotherapy in conjunction with intratumoral injection of an immune adjuvant in the clinically relevant animal model of spontaneously occurring osteosarcoma in client-owned dogs with the intent of priming an adaptive immune response capable of delaying or preventing the occurrence of metastatic disease is demonstrated.

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