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Abstract #4153

Deuterium oxide as a black water contrast medium for real-time MRI-guided endovascular neurointervention

Lin Chen1,2, Jing Liu1,3, Chengyan Chu1,4, Nirhbay Yadav1,2, Jiadi Xu1,2, Monica Pearl1, Piotr Walczak1,4, Peter van Zijl1,2, Miroslaw Janowski4, and Guanshu Liu1,2
1Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3The First Affiliated Hospital of Jinan University, Guangzhou, China, 4Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States

The use of contrast media, such as Gadolinium-based contrast agents (GBCA), superparamagnetic iron oxide particles (SPIO) and carbon dioxide, can improve the conspicuity of MRI, thereby helping to improve the accuracy of transcathether infusions during endovascular neurointerventions. In this study, we exploited deuterium oxide (D2O) as a new MRI contrast medium for guiding intra-arterial hyperosmotic blood brain barrier (BBB) opening in experimental animal models. Compared to the SPIO-based approach, D2O MRI guidance was found to provide comparable results that can predict the territory of BBB opening (assessed by Gd-MRI).

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