Abstract #4153

Deuterium oxide as a black water contrast medium for real-time MRI-guided endovascular neurointervention

Lin Chen^1,2, Jing Liu^1,3, Chengyan Chu^1,4, Nirhbay Yadav^1,2, Jiadi Xu^1,2, Monica Pearl¹, Piotr Walczak^1,4, Peter van Zijl^1,2, Miroslaw Janowski⁴, and Guanshu Liu^1,2

¹Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³The First Affiliated Hospital of Jinan University, Guangzhou, China, ⁴Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States

The use of contrast media, such as Gadolinium-based contrast agents (GBCA), superparamagnetic iron oxide particles (SPIO) and carbon dioxide, can improve the conspicuity of MRI, thereby helping to improve the accuracy of transcathether infusions during endovascular neurointerventions. In this study, we exploited deuterium oxide (D₂O) as a new MRI contrast medium for guiding intra-arterial hyperosmotic blood brain barrier (BBB) opening in experimental animal models. Compared to the SPIO-based approach, D₂O MRI guidance was found to provide comparable results that can predict the territory of BBB opening (assessed by Gd-MRI).

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