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Abstract #4162

In vivo MRI measurement of microstructural constraints for direct drug delivery within the brain

Antonella Castellano1, Alice Segato2, Valentina Pieri1, Marco Vidotto2, Nicolò Pecco1, Marco Riva3,4, Riccardo Secoli5, Davide Danilo Zani6, Stefano Brizzola6, Marco Trovatelli7, Giuliano Ravasio6, Marcello Cadioli8, Lorenzo Bello4,9, Ferdinando Rodriguez Y Baena5, Elena De Momi2, and Andrea Falini1
1Neuroradiology Unit and CERMAC, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy, 3Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy, 4Neurosurgical Oncology Unit, IRCCS Humanitas Clinical and Research Center, Rozzano (MI), Italy, 5Department of Mechanical Engineering, Imperial College London, London, United Kingdom, 6Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy, 7Department of Health, Animal Science and Food Safety, Faculty of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy, 8Philips Healthcare, Milan, Italy, 9Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy

Brain tissue microstructure may influence the efficient delivery of therapeutics within the brain. Diffusion Tensor Imaging (DTI) enables the depiction of tissue properties in vivo, and thus is potentially relevant for planning convection-enhanced delivery (CED) within the brain. We report on the quantitative assessment of the distribution of a Gadolinium solution infused by CED within the brain of a live ovine model. Infusate distributions were measured at multiple timepoints and compared to microstructural properties as depicted by DTI, thus demonstrating the impact of tissue features and catheter positioning on drug distribution in vivo.

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