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Abstract #4163

Magnetic field stimuli improve hepatic delivery of oxaliplatin to colorectal liver metastatic tumor bearing rats

Venkateswara Gogineni1, Dilip Maddirela1, Woo Ram Park2, Jaidip Jagtap1, Abdul Parchur1, Gayatri Sharma1, El-Sayed H Ibrahim1, Amit Joshi1, Andrew Larson2, Dong-Hyun Kim2, and Sarah B White1
1Medical College of Wisconsin, Milwaukee, WI, United States, 2Northwestern University, Chicago, IL, United States

Systemic chemotherapy is the standard of care for the treatment of unresectable metastatic colorectal cancer. However, new drug delivery platforms are needed to mitigate its associated toxicities. In this study, we develop and evaluate a liposome formulation that deliver oxaliplatin under magnetic field stimulus site selectively release in high concentration to alleviate the off-target effects in a rat model of colorectal liver metastases (CRLM). Quantitative MRI enabled assessment of changes in tumor characteristics over time for confirmation of procedural success and proper catheter-selective tumor targeting, which allows for high concentrations of oxaliplatin and improves survival outcomes in CRLM tumor-bearing rats.

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