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Abstract #4164

Diffusion and Dynamic Contrast-enhanced MRI for Evaluation of Prostate Response to 90Yttrium Radioembolization in A Canine Hyperplasia Model

Weiguo Li1,2, Kathleen Harris1, Ali Khan1, Simone Raiter1, Monica Matsumoto3, Andrew C Larson1, and Samdeep Mouli1
1Radiology, Northwestern University, Chicago, IL, United States, 2Research Resource Centers, University of Illinois at Chicago, Chicago, IL, United States, 3Radiology, University of Chicago, Chicago, IL, United States

Management options for localized prostate cancer have largely remained the same for the past 30 years. 90Yttrium (90Y) radioembolization is a novel radiotherapy approach that offers the potential to deliver high-dose radiation therapy with minimal non-target radiation. However, currently no accurate way exists to evaluate radiation effects noninvasively following embolization. In this study, we sought to apply diffusion and dynamic contrast-enhanced perfusion MRI to investigate assess the effects of treatment following 90Y prostate artery radioembolization in a dog prostate model.

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