Abstract #4164

Diffusion and Dynamic Contrast-enhanced MRI for Evaluation of Prostate Response to 90Yttrium Radioembolization in A Canine Hyperplasia Model

Weiguo Li^1,2, Kathleen Harris¹, Ali Khan¹, Simone Raiter¹, Monica Matsumoto³, Andrew C Larson¹, and Samdeep Mouli¹

¹Radiology, Northwestern University, Chicago, IL, United States, ²Research Resource Centers, University of Illinois at Chicago, Chicago, IL, United States, ³Radiology, University of Chicago, Chicago, IL, United States

Management options for localized prostate cancer have largely remained the same for the past 30 years. ⁹⁰Yttrium (⁹⁰Y) radioembolization is a novel radiotherapy approach that offers the potential to deliver high-dose radiation therapy with minimal non-target radiation. However, currently no accurate way exists to evaluate radiation effects noninvasively following embolization. In this study, we sought to apply diffusion and dynamic contrast-enhanced perfusion MRI to investigate assess the effects of treatment following ⁹⁰Y prostate artery radioembolization in a dog prostate model.

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