Abstract #4297

SNR efficient diffusion imaging at 7T with B1+ mitigated multi-shot SMS-EPI, using semi adiabatic PINS RF and low-rank completion reconstruction

SoHyun Han¹, Rebecca E. Feldman², Mary Kate Manhard^3,4, Congyu Liao^3,4, Seong-Gi Kim¹, Priti Balchandani⁵, and Kawin Setsompop^3,4

¹Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, ²Department of Computer Science, Mathematics, Physics, and Statistics, University of British Columbia, Kelowna, BC, Canada, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁵Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

B₁⁺ inhomogeneity, SAR, and shortened T₂-relaxation are the main challenges to leverage the higher SNR at ultra-high-field MRI. Here, we develop a new method by combining navigation-free multi-shot SMS-EPI with low-rank matrix completion reconstruction with semi-adiabatic PINS pulse for B₁⁺ insensitive SMS imaging. Using this combined approach, we demonstrated mitigated B₁⁺ inhomogeneity by comparing with conventional-SE pulse and the feasibility of low-rank completion reconstruction at high b-value. Finally, 1.2 mm isotropic whole-brain diffusion MRI was acquired across 64 diffusion directions with high-SNR in 11 minutes at 7T.

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