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Abstract #4297

SNR efficient diffusion imaging at 7T with B1+ mitigated multi-shot SMS-EPI, using semi adiabatic PINS RF and low-rank completion reconstruction

SoHyun Han1, Rebecca E. Feldman2, Mary Kate Manhard3,4, Congyu Liao3,4, Seong-Gi Kim1, Priti Balchandani5, and Kawin Setsompop3,4
1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Department of Computer Science, Mathematics, Physics, and Statistics, University of British Columbia, Kelowna, BC, Canada, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

B1+ inhomogeneity, SAR, and shortened T2-relaxation are the main challenges to leverage the higher SNR at ultra-high-field MRI. Here, we develop a new method by combining navigation-free multi-shot SMS-EPI with low-rank matrix completion reconstruction with semi-adiabatic PINS pulse for B1+ insensitive SMS imaging. Using this combined approach, we demonstrated mitigated B1+ inhomogeneity by comparing with conventional-SE pulse and the feasibility of low-rank completion reconstruction at high b-value. Finally, 1.2 mm isotropic whole-brain diffusion MRI was acquired across 64 diffusion directions with high-SNR in 11 minutes at 7T.

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