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Abstract #4300

Time-dependent and anisotropic diffusion in the heart: linear and spherical tensor encoding with varying degree of motion compensation

Samo Lasic1,2, Henrik Lundell2, Filip Szczepankiewicz3,4,5, Markus Nilsson3, J├╝rgen E. Schneider6, and Irvin Teh6
1Random Walk Imaging, Lund, Sweden, 2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 3Clinical Sciences, Lund University, Lund, Sweden, 4Harvard Medical School, Boston, MA, United States, 5Brigham and Women's Hospital, Boston, MA, United States, 6Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom

Spherical tensor encoding (STE) can potentially shorten acquisition of mean diffusivity (MD) compared to the traditional linear tensor encoding (LTE). To avoid negative effects of motion, e.g. in the heart, motion compensation is needed. However, motion compensation requires altering diffusion gradient waveforms and their sensitivities to time-dependent diffusion. To exclude motion, we first investigated LTE and STE with different degrees of motion compensation in ex vivo pig hearts. We observed significantly different MD, which can be attributed to time-dependent diffusion and microscopic diffusion anisotropy. Our analysis suggests that time-dependent diffusion is a critical determinant of MD in the myocardium.

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