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Abstract #4299

Rapid DTI-based free water elimination and mapping with explicit T2 modelling using a dual-echo Stejskal-Tanner EPI sequence

Ezequiel Farrher1, Richard P. Buschbeck1, Kuan-Hung Cho2, Ming-Jye Chen2, Seong Dae Yun1, Zaheer Abbas1, Chang-Hoon Choi1, Li-Wei Kuo2,3, and N. Jon Shah1,4,5,6
1Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, Germany, 2Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 3Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 4Department of Neurology, RWTH Aachen University, Aachen, Germany, 5JARA - BRAIN - Translational Medicine, Aachen, Germany, 6Institute of Neuroscience and Medicine 11, JARA, Forschungszentrum Jülich, Jülich, Germany

We propose and investigate a dual-echo (DE) Stejskal-Tanner EPI sequence for rapid DTI-based free water elimination and mapping with explicit T2 modelling (FWET2) in vivo. DTI maps from the DE sequence are artefact-free and similar to the standard, individual echo (IE) approach. Compared to the IE case, an underestimation of T2 values calculated from the DE sequence is observed. The T2 underestimation stems from reduced signal amplitudes in the second echo of the DE sequence, which we demonstrate to correlate with imperfect refocusing RF pulses. A simple correction method is proposed. FWET2 model parameters derived from both sequences are comparable.

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