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Abstract #4305

Reproducibility of Diffusion MRI Metrics Using 4-way Phase-Encoding Acquisition Design

M. Okan Irfanoglu1, Neda Sadeghi2, Joelle Sarlls3, and Carlo Pierpaoli2
1QMI, NIBIB/NIH, Bethesda, MD, United States, 2NIBIB/NIH, Bethesda, MD, United States, 3NINDS/NIH, Bethesda, MD, United States

In this work, we assessed the reproducibility of diffusion MRI metrics w.r.t different experimental and acquisition designs within the same scan time limits. The design that employed identical diffusion gradients and b-values for blip-up phase-encoding and blip-down phase-encoding provided significant improvements in terms of data reproducibility compared to the design using a single b=0 blip-down image in terms of distortions. The proposed 4-way encoding scheme not only improved upon this design but also consistently reduced the effects of other imaging artifacts; therefore, is suggested to be the acquisition scheme of choice for dMRI studies where biological differences are subtle.

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