Abstract #4307

Practical considerations of DW-MRS with ultra-strong diffusion gradients

Christopher Jenkins¹, Elena Kleban¹, Lars Mueller¹, John Evans¹, Umesh Rudrapatna¹, Derek Jones¹, Francesca Branzoli², Itamar Ronen³, and Chantal M.W Tax¹

¹CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, ²Centre for NeuroImaging Research - CENIR, Brain and Spine Institute - ICM, Paris, France, ³Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Diffusion-weighted magnetic resonance spectroscopy benefits from the use of ultra-strong gradients. Slow diffusing metabolites necessitate a large range of b-values to accurately model the diffusion properties. Ultra-strong gradients open the possibility of higher b-values and reduced diffusion times, alleviating some of these constraints. We present initial data acquired with DW-PRESS on a 300mT/m gradient Connectom scanner, and introduce the practical considerations associated with ultra-strong gradients.

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