While most brain imaging sequences now favor their 3D counterparts, diffusion imaging is an exception. This is due to large diffusion gradients resulting in increased sensitivity to motion exhibited by 3D acquisition. Prior schemes have used limited brain coverage and/or triggering or acquired multiple 3D slabs along with modified reconstruction schemes. The modified sequence used here employs first-order motion compensated diffusion gradients in addition to real-time alignment to acquire whole brain 3D-DWI images as a single slab. Relatively shorter TE (using enhanced gradients) and TR along with other modifications result in faster, reduced artifact diffusion images while providing higher SNR.