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Abstract #4326

Investigating restricted diffusion within different cortical regions using double-diffusion encoding

Qiuyun Fan1, Thomas Witzel1, Slimane Tounekti1, Qiyuan Tian1, Chanon Ngamsombat1, Maya Polackal1, Aapo Nummenmaa1, and Susie Huang1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

We report the acquisition of whole brain, 2-mm isotropic resolution DDE data in a healthy volunteer using an orientationally invariant sampling scheme and quantify the mean DDE signal intensity across cortical regions as a measure of diffusion restriction within different cortices. Higher mean signal intensities were observed in the cerebellum and limbic cortices, which are thought to reflect a higher degree of restriction in the tissue microstructural environment and may correspond to densely packed, small granule and pyramidal cells known to be present in these regions.

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