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Abstract #4327

Radial diffusion-weighted MRI enables motion-robustness and reproducibility for orthotopic pancreatic cancer in mouse

Jianbo Cao1, Stephen Pickup1, Hanwen Yang1, Victor Castillo1, Cynthia Clendenin2,3, Peter O’Dwyer2,3, Mark Rosen1,3, and Rong Zhou1,3
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Pancreatic Cancer Research Center, University of Pennsylvania, Philadelphia, PA, United States, 3Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, United States

Diffusion weighted (DW)-MRI is sensitive to tumor microenvironment (TME) thus useful for assessing pancreatic cancer responses to stroma-directed drugs, as they change TME by degradation or reduction of extracellular matrix. Motion-sensitive location of pancreatic tumor and fast respiration rate of mice impose a big challenge for quantitative DW-MRI. We compared radial k-space and echo-planar imaging based DW protocol for their accuracy and test-retest reproducibility. EPI-DW consistently underestimates water ADC value at 37C (reference to literature) where radial-DW does not. Better test-retest producibility measured by within-subject CV is obtained with radial-DW compared to EPI-DW.

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