Diffusion weighted (DW)-MRI is sensitive to tumor microenvironment (TME) thus useful for assessing pancreatic cancer responses to stroma-directed drugs, as they change TME by degradation or reduction of extracellular matrix. Motion-sensitive location of pancreatic tumor and fast respiration rate of mice impose a big challenge for quantitative DW-MRI. We compared radial k-space and echo-planar imaging based DW protocol for their accuracy and test-retest reproducibility. EPI-DW consistently underestimates water ADC value at 37C (reference to literature) where radial-DW does not. Better test-retest producibility measured by within-subject CV is obtained with radial-DW compared to EPI-DW.