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Abstract #4328

Correction for the influence of transmit-inhomogeneity in DW-SSFP on signal and ADC estimates in whole post-mortem brains at 7T

Benjamin C Tendler1, Sean Foxley2, Moises Hernandez-Fernandez3, Michiel Cottaar1, Olaf Ansorge4, Saad Jbabdi1, and Karla Miller1
1Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Department of Radiology, University of Chicago, Chicago, IL, United States, 3Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, United States, 4Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Diffusion-weighted steady-state free precession (DW-SSFP) generates high SNR diffusivity estimates in whole, post-mortem human brains. Improved estimates at 7T has motivated its use at ultra-high field. However, the DW-SSFP signal has a strong dependence on flip angle. This translates into both variable signal amplitude and diffusion contrast. At 7T, transmit-($$$B_{1}^{+}$$$) inhomogeneity leads to $$$B_{1}^{+}$$$-dependent SNR and ADC estimates. Previous work corrected for $$$B_{1}^{+}$$$-inhomogeneity by acquiring DW-SSFP datasets at two flip angles. Here, this approach is extended, utilising the full Buxton model of DW-SSFP to model non-Gaussian diffusion. A noise-floor correction and signal weighting are also incorporated to improve diffusivity estimates.

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