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Abstract #4331

Single-Shot Diffusion-Weighted Spatiotemporal Encoding (SPEN) using Polarities Average Mode (PAM) to Correct Spatial-Dependent b-Values

Lisha Yuan1, Yi-Cheng Hsu2, Dan Wu1, Hongjian He1, and Jianhui Zhong1,3
1Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China, 2MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, 3Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Compared to traditional echo-planar imaging (EPI)-based schemes, spatiotemporal encoding (SPEN) is largely insensitive to magnetic field and chemical shift heterogeneities. However, excitation gradient has different effects for each position, thus the interaction between imaging and diffusion gradients introduces spatial-dependent diffusion weightings along the SPEN axis. A new method named polarities average mode (PAM) was proposed to obtain accurate apparent diffusion coefficient (ADC) map, with two acquisitions of different polarities between excitation and diffusion gradients. Simulation, phantom, and human experiments were designed to assess method performance. The proposed method enables SPEN to obtain ADC maps easily and accurately.

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