To evaluate the feasibility of applying simultaneous multi-slice (SMS) single-shot echo planar imaging (EPI) to accelerate MR diffusion imaging for breast carcinoma, fibroadenoma of breast and normal breast. SMS sequences with double and triple acceleration were compared with conventional DWI sequences, respectively. These SMS DWI sequences were compared to conventional DWI in terms of image quality parameters (5-point Likert scale) and SNR, ADC measurements. Comparing with conventional EPI-DWI, the SMS markedly reduces the diffusion scan time and the image SNR still shows a good quality. Thus, SMS technique is recommended for DWI of the MR breast examinations.