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Abstract #4364

Highly Accelerated and High-Quality Intra-voxel Incoherent Motion DWI Enabled by Parametric POCS based multiplexed sensitivity-encoding

Shihui Chen1, Mei-Lan Chu2, Chun-Jung Juan3, Liyuan Liang1, and Hing-Chiu Chang1
1The University of Hong Kong, Hong Kong, Hong Kong, 2Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan, 3Department of Medical Imaging, China Medical University Hsinchu Hospital, Taiwan, Taipei, Taiwan

Low SNR and long acquisition time hinder the clinical feasibility of intra-voxel incoherent motion (IVIM) diffusion-weighted imaging. In this work, we used a joint reconstruction framework based on POCSMUSE algorithm to simultaneously reconstruct under-sampled multi-b multi-shot DW-EPI data without undesired noise amplification. A proposed parametric correction scheme (PCS) was incorporated into POCSMUSE algorithm for robust reconstruction based on either conventional bi-exponential or simplified IVIM model. The proposed method demonstrated that the high-quality brain IVIM images could be reconstructed from highly accelerated (R=4) data acquired with multi-b multi-shot DW-EPI.

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