Low SNR and long acquisition time hinder the clinical feasibility of intra-voxel incoherent motion (IVIM) diffusion-weighted imaging. In this work, we used a joint reconstruction framework based on POCSMUSE algorithm to simultaneously reconstruct under-sampled multi-b multi-shot DW-EPI data without undesired noise amplification. A proposed parametric correction scheme (PCS) was incorporated into POCSMUSE algorithm for robust reconstruction based on either conventional bi-exponential or simplified IVIM model. The proposed method demonstrated that the high-quality brain IVIM images could be reconstructed from highly accelerated (R=4) data acquired with multi-b multi-shot DW-EPI.
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