The purpose of this study is to demonstrate automatic segmentation for reduced diffusion and perfusion areas in ischemic stroke brains with pattern-recognition (constrained non-negative matrix factorization (cNMF)) to directional intravoxel incoherent motion MRI (IVIM-MRI). The robustness of region segmentation with pattern-recognition was observed in both simulations and in vivo experiments. Using pattern-recognition analysis of IVIM signal, white matter in which flow may have been aligned, and lesion regions are automatically segmented in ischemic stroke brain. In this study, we successfully implemented pattern-recognition to directional IVIM signals.
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