The objective of this study is to investigate differences in white matter (WM) integrity between Alzheimer’s disease (AD) and healthy subjects (HC) using diffusion tensor imaging (DTI) metrics from standard DTI and free-water (FW)-DTI. Regional changes in DTI metrics were found with both standard and FW-DTI, while FW-DTI improves the reliability and inter-parameter consistency of DTI metrics in the presence of atrophy. We hypothesize that the implementation of FW correction algorithm for DTI may provide more sensitive and specific insight into AD-related pathological changes in WM.
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