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Abstract #4380

Reproducibility crisis in diffusion MRI: Contribution of software processing pipelines

Suheyla Cetin Karayumak1,2, Lily O’Sullivan2, Monica Gabriella Lyons2, Tashrif Billah2, Ofer Pasternak1,2, Sylvain Bouix1,2, Marek Kubicki1,2, and Yogesh Rathi1,2
1Harvard Medical School, Boston, MA, United States, 2Brigham and Women's Hospital, Boston, MA, United States

This study attempts to highlight the reproducibility problem in clinical diffusion MRI studies by comparing different software in a large diffusion MRI data, collected from multiple sites with 291 schizophrenia patients and 251 healthy controls. We fit diffusion tensor using FSL, MRtrix and Slicer with ordinary-least-squares (OLS) and weighted-least-squares (WLS) methods. To assess biological differences (measured by FA) between controls and patients, we computed effect-sizes (Cohen’s d) at each site using each software. We observed significant software effects with each software package producing significantly different results, when either OLS or WLS, was used.

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