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Abstract #4381

Diffusion MRI response function estimates vary more across pathways than across subjects

Kurt G Schilling1, Bennett A Landman1,2,3,4, Alexander Leemans5, Adam W Anderson1,2, and Chantal M.W. Tax6
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 3Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 4Electrical Engineering, Vanderbilt University, Nashville, TN, United States, 5Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 6CUBRIC, School of Physics, Cardiff University, Cardiff, United Kingdom

We investigated the diffusion fiber response function by characterizing the modelled diffusivity, the shape, and the size of the diffusion signal in regions of single fiber populations. We show that the various descriptors of the diffusion signal vary significantly across white matter pathways within a subject, and across subjects for a given pathway. Analysis of variance suggests that variability between pathways is greater than across subjects. Understanding the response function and its variation are necessary for accurate fiber orientation characterization, as well as characterizing microstructural effects from geometrical effects within a voxel.

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