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Abstract #4382

High-resolution microscopic diffusion anisotropy imaging in the human hippocampus using multidimensional diffusion encoding

Jiyoon Yoo1, Leevi Kerkelä1, Patrick W. Hales1, Kiran K. Seunarine1, Noemi G. Gyori1,2, Enrico Kaden2, and Christopher A. Clark1
1UCL Great Ormond Street Institute of Child Health, London, United Kingdom, 2UCL Centre for Medical Image Computing, London, United Kingdom

Several neurological diseases are associated with microstructural changes in the hippocampus which can be observed using diffusion MRI. However, DTI derived microstructural metrics such as fractional anisotropy (FA) are not able to differentiate between orientation dispersion and microscopic anisotropy. In this study, we applied an optimised multidimensional diffusion encoding sequence to measure microscopic fractional anisotropy (µFA) and normalised size variance (CMD) in the human hippocampus of healthy subjects. We also defined a clinically feasible acquisition protocol by subsampling the full data set.

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