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Abstract #4383

Quantifying whole-brain microstructural changes in rat model of focal ischemia on unilateral motor cortex using diffusion MRI at 14T

Zhaoqing Li1, Huan Gao2, Kedi Xu2, and Ruiliang Bai1,3
1Interdisciplinary Institute of Neuroscience and Technology (ZIINT), College of Biomedical Engineering and Instrument Science, Zhejiang University, HangZhou, China, 2Qiushi Academy for Advanced Studies (QAAS), Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, HangZhou, China, 3School of Medicine, Zhejiang Univerisity, HangZhou, China

Focal cortical ischemia animal model has been widely used to study neuroanatomical reorganization of cortex with intracortical microstimulation. However, the whole-brain structural changes following focal ischemia on motor cortex is unknown. In this study, high-resolution DTI is performed on focal unilateral motor cortex ischemia rat model at 14T. Voxel-wise based analysis (VBA) and VBA-guided connectivity analysis are performed to explore potential whole-brain microstructure and global structural connectivity changes. Our results show that large-scale white matter microstructural changes mainly distribute in corpus callosum, external capsule, cerebral peduncle. Significant reorganization of sensorimotor network associated with these regions were also found after ischemia.

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